Photomodulation of lymphatic delivery of liposomes to the brain bypassing the blood-brain barrier: new perspectives for glioma therapy

Abstract The blood-brain barrier (BBB) has a significant contribution to the protection of central nervous system (CNS). However, it also limits brain drug delivery and thereby complicates treatment CNS diseases. development safe methods for an effective medications nanocarriers can be revolutionary step in overcoming this limitation. Here, we report unique properties lymphatic deliver tracers liposomes meninges, tissues, glioma rats. Using quantum-dot-based 1267 nm laser (for photosensitizer-free generation singlet oxygen), clearly demonstrate photostimulation as well clearance from brain. These pilot findings open promising perspectives photomodulation drugs pathology bypassing BBB. “smart” with antitumor new tumor branches might breakthrough strategy therapy gliomas.